Multiple Imputation for General Missing Data Patterns in the Presence of High-dimensional Data

نویسندگان

  • Yi Deng
  • Changgee Chang
  • Moges Seyoum Ido
  • Qi Long
چکیده

Multiple imputation (MI) has been widely used for handling missing data in biomedical research. In the presence of high-dimensional data, regularized regression has been used as a natural strategy for building imputation models, but limited research has been conducted for handling general missing data patterns where multiple variables have missing values. Using the idea of multiple imputation by chained equations (MICE), we investigate two approaches of using regularized regression to impute missing values of high-dimensional data that can handle general missing data patterns. We compare our MICE methods with several existing imputation methods in simulation studies. Our simulation results demonstrate the superiority of the proposed MICE approach based on an indirect use of regularized regression in terms of bias. We further illustrate the proposed methods using two data examples.

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عنوان ژورنال:

دوره 6  شماره 

صفحات  -

تاریخ انتشار 2016